Southern First Bancshares operates in two markets: Greenville, South Carolina, where it operates under the Greenville First Bank moniker, and in Columbia, South Carolina as Southern First Bank. Selling itself as a local alternative to larger institutions, the company, which has more than five bank branches, targets individuals and small to midsized businesses. It offers traditional deposit services and products, including checking accounts, savings accounts, and CDs. The banks use funds from deposits mainly to write commercial mortgages, residential mortgages, and commercial business loans.